Hippocampal glutamate is increased and associated with risky drinking in young adults with major depression

DF Hermens; KM Chitty; RS Lee; A Tickell; PS Haber; SL Naismith; IB Hickie; J Lagopoulos

Journal article

Hippocampal glutamate is increased and associated with risky drinking in young adults with major depression

DF Hermens, KM Chitty, RS Lee, A Tickell, PS Haber, SL Naismith, IB Hickie, J Lagopoulos

Journal of Affective Disorders | ELSEVIER SCIENCE BV | Published : 2015

DOI: 10.1016/j.jad.2015.07.009

Abstract

Abstract Background Risky drinking in young people is harmful, highly prevalent and often complicated by comorbid mental health problems that compound alcohol-induced impairment. The hippocampus and the glutamate system have been implicated in the pathophysiology of alcoholism and depression. This study aimed to determine whether risky drinking is associated with glutamate levels recorded within the hippocampus of young adults with major depression. Methods Sixty-three young persons with major depression (22.1±3.1 years; 65% female) and 38 healthy controls were recruited. Participants completed the alcohol use disorder identification test and underwent proton magnetic resonance spectroscopy ..

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University of Melbourne Researchers

Rico Lee Author

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Grants

Awarded by Community Mental Health Drug and Alcohol Research Network

Funding Acknowledgements

This work was funded by a grant from the NSW Ministry of Health, Mental Health and Drug and Alcohol Office as well as National Health and Medical Research Council program (No. 566529) and Centres of Clinical Research Excellence (No. 264611) grants. DFH was supported by a grant from the NSW Ministry of Health, Mental Health and Drug and Alcohol Office; SLN was supported by an NHMRC Career Development Award (No. 402864); and IBH was supported by an NHMRC Senior Principal Research Fellowship (No. 1046899). These funding agencies had no role in the analysis or interpretation of these data; or in the writing of this report; or the decision to submit the paper for publication.